Salicylic Acid Versus Cryotherapy for the Treatment of HPV1-induced Plantar Warts

The 306 Hospital of People's Liberation Army

Status: Not yet enrolling

Conditions: Warts

Treatments: Other: salicylic acid; Other: cryotherapy

Study type: Interventional

Funder types: Other

Identifiers

NCT05617950

306PLA-005

Details and patient eligibility

About

To evaluate whether salicylic acid was superior to cryotherapy for plantar warts

Full description

Patients with plantar warts were randomized equally to receive salicylic acid or cryotherapy. Cryotherapy is delivered by a technician up to a maximum of four treatments 3 weeks apart. Thirty percent of salicylic acid is applied once daily by the patient (or parent) for a maximum of 12 weeks. The primary outcomes were the cure rates at 12 weeks; secondary outcomes included time to clearance of warts, patient satisfaction with the treatment and treatment-related adverse effects.

Enrollment: 174 estimated patients

Sex: All

Ages: 12+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with HPV1-induced plantar warts.
• Total number of warts is ≤5.
• Aged 12 years or older.

Exclusion criteria

• Patients are currently participating in another trial for the treatment of plantar warts.
• Patients had received two or more consecutive sessions of cryotherapy, with an interval of no more than 4 weeks (The history of salicylic acid treatment was not considered as criteria for exclusion because high concentration salicylic acid is not commercially available in Chinese mainland).
• Patients have taken immunosuppressant drugs (such as oral corticosteroids) during the past three months.
• Patients have impaired healing eg due to diabetes, vitamin A deficiency, hyperthyroidism and hypothyroidism.
• Patients have autoimmune diseases (such as systemic lupus erythematosus, dermatomyositis, scleroderma or other diseases).
• Patients are pregnant or ready for pregnancies or breast-feeding.
• Patients have cold intolerance (such as cold urticaria, cryoglobulinaemia, cold agglutinin syndrome or Raynaud's syndrome).
• Patients have local pain intolerance.
• Patients have local hypoesthesia.
• Patients are unable to tolerate salicylic acid or cryotherapy.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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174 participants in 2 patient groups

salicylic acid

Experimental group

Description:

30% salicylic acid

Treatment:

Other: salicylic acid

cryotherapy

Active Comparator group

Description:

liquid nitrogen

Treatment:

Other: cryotherapy