Saline Challenge in Monitoring Asthma Control

Kuopio University Hospital

Status: Completed

Conditions: Asthma

Treatments: Drug: budesonide

Study type: Interventional

Funder types: Other

Identifiers

NCT00859274

KUH5801112

Details and patient eligibility

About

It is generally accepted that symptoms and lung function are not sufficient ways to monitor asthma control. Therefore, several objective tests have been developed to help asthma control monitoring, each having their own shortcomings. We have developed a new test, the hypertonic saline cough challenge. In our previous publication this test has proven useful in diagnosing asthma. The present study is planned to investigate whether hypertonic saline cough challenge could be used to monitor asthma control. A group of steroid-naive asthmatics will be recruited. A treatment with inhaled budesonide is started. Asthma control is monitored at regular intervals utilising a validated questionnaire. At the same time points, hypertonic saline cough challenges will be performed. We will analyse whether changes in the responsiveness to the cough challenge reflects the changes in asthma control

Enrollment: 40 patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• symptomatic asthma

Exclusion criteria

• usage of inhaled or oral corticosteroids
• recent febrile respiratory infection
• severe, unstable asthma

Trial design

Primary purpose: Basic Science

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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40 participants in 1 patient group

Budesonide

Experimental group

Description:

All patients receive this treatment to induce a change in asthma control

Treatment:

Drug: budesonide