Saline Challenge in Monitoring Asthma Control

K

Kuopio University Hospital

Status

Completed

Conditions

Asthma

Treatments

Drug: budesonide

Study type

Interventional

Funder types

Other

Identifiers

NCT00859274
KUH5801112

Details and patient eligibility

About

It is generally accepted that symptoms and lung function are not sufficient ways to monitor asthma control. Therefore, several objective tests have been developed to help asthma control monitoring, each having their own shortcomings. We have developed a new test, the hypertonic saline cough challenge. In our previous publication this test has proven useful in diagnosing asthma. The present study is planned to investigate whether hypertonic saline cough challenge could be used to monitor asthma control. A group of steroid-naive asthmatics will be recruited. A treatment with inhaled budesonide is started. Asthma control is monitored at regular intervals utilising a validated questionnaire. At the same time points, hypertonic saline cough challenges will be performed. We will analyse whether changes in the responsiveness to the cough challenge reflects the changes in asthma control

Enrollment

40 patients

Sex

All

Ages

18 to 90 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • symptomatic asthma

Exclusion criteria

  • usage of inhaled or oral corticosteroids
  • recent febrile respiratory infection
  • severe, unstable asthma

Trial design

Primary purpose

Basic Science

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

40 participants in 1 patient group

Budesonide
Experimental group
Description:
All patients receive this treatment to induce a change in asthma control
Treatment:
Drug: budesonide

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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