Salivary and Serum Levels of Chemerin and MMP-9 in Oral Premalignant and Malignant Lesions

Cairo University (CU)

Status: Completed

Conditions: Precancerous Conditions; Oral Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT02323672

chemerin_MMP-9_Oral_cancer

Details and patient eligibility

About

45 individuals were subdivided into 3 groups, 15 patients with oral premalignant lesions, 15 patients with oral malignant lesions and 15 control individuals. Levels of chemerin and MMP-9 were evaluated in serum and saliva of these subjects utilizing the ELISA technique.

Full description

45 individuals were subdivided into 3 groups, 15 patients suffering from oral premalignant lesions, 15 patients suffering from oral malignant lesions and 15 individuals having age, gender and periodontal status matched with both patients groups acting as a control group. Serum and whole unstimulated saliva samples were collected from all the included groups in order to determine chemerin and MMP-9 in serum and saliva utilizing the ELISA technique.

Enrollment: 45 patients

Sex: All

Ages: 40 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• patients with oral premalignant lesions.
• patients with oral malignant lesions.

Exclusion criteria

• any systemic disease other than oral premalignant or malignant lesions. smokers. pregnant females. periodontal diseases.

Trial design

45 participants in 3 patient groups

oral premalignant patients

Description:

15 patients suffering from oral premalignant lesions as lichen planus, actinic keratosis, leukoplakia and erythroplakia.

oral malignant patients

Description:

15 patients suffering from oral malignant lesions

control subjects

Description:

15 individuals age, gender and periodontal status matched with oral premalignant and malignant patients and not suffering from any oral mucosal lesions or periodontal disease.