Salivary Antioxidant Capacity Before and After Complete Dental Rehabilitation

Riyadh Colleges of Dentistry and Pharmacy

Status: Completed

Conditions: Dental Caries in Children

Treatments: Procedure: Dental rehabilitation under general anesthesia

Study type: Observational

Funder types: Other

Identifiers

NCT03432728

FPGRP/ /43435005/126

Details and patient eligibility

About

Salivary samples were obtained from 20 children in their fifth year of life diagnosed S-ECC and 20 age and sex matched controls. Complete dental rehabilitation under general anesthesia was performed for the 20 children with S-ECC, and follow up salivary samples were obtained one week and three months post operatively. The TAC was measured using a commercially available Oxygen Radical Absorbance Antioxidant Assay measurement kit (Zen-Bio ORAC™, AMS Biotechnology, Abington UK).

Full description

Background: The association of total salivary antioxidant capacity (TAC) to severe early childhood caries (S-ECC) has been studied in the past. It is not clear if TAC is an indicator of the inflammatory response to the lesion or a marker of the disease.

Aim: This study aimed to measure the salivary TAC levels in children with early childhood caries before and after dental treatment and compare the results to caries free children.

Methodology: Salivary samples were obtained from 20 children in their fifth year of life diagnosed S-ECC and 20 age and gendersex matched controls. Complete dental rehabilitation under general anesthesia was performed for the 20 children with S-ECC, and follow up salivary samples were obtained one week and three months post operatively. The TAC was measured using a commercially available Oxygen Radical Absorbance Antioxidant Assay measurement kit (Zen-Bio ORAC™, AMS Biotechnology, Abington UK).

Enrollment: 40 patients

Sex: All

Ages: 60 to 72 months old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Medically fit children
• Age below 71 months
• Test group - to be diagnosed with severe ECC
• Control group - to be caries free

Exclusion Criteria:

Trial design

40 participants in 2 patient groups

S-ECC

Description:

Children in their fifth year of life with severe early childhood caries Children selected will require complete dental rehabilitation under general anesthesia All enrolled children will receive treatment of all dental carious lesions under general anesthesia

Treatment:

Procedure: Dental rehabilitation under general anesthesia

Control

Description:

Children age and sex matched with the S-ECC group who are free of dental caries