Salivary Bacterial Associations to Short Term Discontinuation of Self-performed Oral Hygiene

University of Copenhagen

Status: Completed

Conditions: Mouth Diseases

Treatments: Procedure: Oral hygiene discontinuation group

Study type: Interventional

Funder types: Other

Identifiers

NCT02913235

UCPH_OI_002

Details and patient eligibility

About

The purpose of the present investigation is to record and compare bacterial compositions in supragingival plaque samples and saliva samples in subjects discontinuing regular oral hygiene for 10 days. The hypothesis is that the composition of the salivary microbiota might reflect local bacterial alterations in relation to discontinuation of oral hygiene.

Full description

35 orally healthy individuals will be enrolled in this study, in which they will discontinue regular oral hygiene procedures for a period of 10 days. Clinical registrations and collection of microbiological samples (supragingival and saliva) will be performed at baseline and 4, 7 and 10 days after discontinuation of regular oral hygiene, and will be repeated 14 days after regular oral hygiene has been resumed.

Enrollment: 30 patients

Sex: All

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Oral and systemically healthy individuals

Exclusion criteria

• Periodontitis
• Dental caries
• Systemic diseases or medications with known associations to oral health
• Antibiotics within the latest 6 month

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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30 participants in 1 patient group

Oral hygiene discontinuation group

Experimental group

Description:

The intervention of the present study is discontinuation of regular oral hygiene procedures for a period of 10 days. Discontinuation of oral hygiene will allow undisturbed biofilm formation (supragingival dental plaque) along the gingival margin of the teeth. After 10 days all individuals will resume regular oral hygiene. Clinical registrations and collection of microbiological samples (supragingival and saliva) will be performed at baseline and 4, 7 and 10 days after discontinuation of regular oral hygiene, and will be repeated 14 days after regular oral hygiene has been resumed.

Treatment:

Procedure: Oral hygiene discontinuation group