Salivary Bacterial Profiles in Relation to Periodontal Treatment

University of Copenhagen

Status: Completed

Conditions: Periodontitis

Treatments: Procedure: Conventional periodontal treatment

Study type: Interventional

Funder types: Other

Identifiers

NCT02913248

UCPH_OI_001

Details and patient eligibility

About

The purpose of the present investigation is to record and compare bacterial compositions in subgingival plaque samples and saliva samples in subjects receiving periodontal treatment. The hypothesis is that the composition of the salivary microbiota might reflect local bacterial alterations in relation to periodontal treatment.

Full description

In this study we plan to enroll 35 subjects with manifest periodontitis, which will be treated according to national and international guidelines. Clinical registration and collection of subgingival plaque samples and saliva samples will be performed at baseline and 2, 6 and 12 weeks after treatment.

Enrollment: 30 patients

Sex: All

Ages: 40 to 99 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Manifest chronic periodontitis according to international classification

Exclusion criteria

• Other treatment requiring oral conditions
• Systemic antibiotics within the latest 6 months
• Systemic diseases and medications with known associations to periodontitis
• Pregnancy and breastfeeding

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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30 participants in 1 patient group

Conventional periodontal treatment

Experimental group

Description:

35 subjects diagnosed with manifest periodontitis, which will all receive standardized treatment according to protocol. In brief, this treatment includes professional tooth cleaning and thorough instruction in self-performed oral hygiene procedures. Clinical registrations and collection of microbiological samples (subgingival and saliva) will performed at baseline and 2, 6 and 12 weeks after treatment.

Treatment:

Procedure: Conventional periodontal treatment