Salivary C- Reactive Protein, Mean Platelet Volume and Neutrophil Lymphocyte Ratio as Diagnostic Markers for Neonatal Sepsis

Cairo University (CU)

Status: Unknown

Conditions: Neonatal Sepsis

Treatments: Diagnostic Test: Salivary CRP

Study type: Observational

Funder types: Other

Identifiers

NCT04800445

MS-53-2020

Details and patient eligibility

About

To evaluate reliability of salivary C-reactive protein ,mean platelet volume , neutrophil -lymphocyte ratio , and platelet lymphocyte ratio in diagnosis of neonatal sepsis

Enrollment: 80 patients

Sex: All

Ages: 1 to 28 days old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• • Full term neonates of both genders from birth to the 28th day of life diagnosed with sepsis by history, clinical findings, laboratory findings, and blood culture. The clinical findings included the presence of three or more of the following:
• (1) temperature instability (hypothermia, hyperthermia) .
• (2) respiratory alterations (grunting, intercostal retractions, apnea, tachypnea, cyanosis) .
• (3) cardiovascular alterations (bradycardia, tachycardia, poor perfusion, hypotension) .
• (4) neurologic alterations (hypotonia, lethargy, seizures)
• (5) gastrointestinal alterations (feeding intolerance, abdominal distension). CRP values >10 mg/L were considered to be positive.

Exclusion criteria

• • Preterm neonates .
• Neonates with CNS malformations, metabolic disorders, chromosomal abnormalities, intrauterine growth restriction, or birth asphyxia were excluded from the study

Trial design

80 participants in 2 patient groups

Case group of fullterm neonates with neonatal sepsis

Treatment:

Diagnostic Test: Salivary CRP

Healthy fullterm neonates

Treatment:

Diagnostic Test: Salivary CRP