Salivary Cortisol As a Biomarker in Patients with Temporomandibular Disorder

University of Coimbra

Status: Enrolling

Conditions: Temporomandibular Joint Disorder

Study type: Observational

Funder types: Other

Identifiers

NCT06874868

FMUCMD2025

Details and patient eligibility

About

t is recognized that cortisol, a hormone produced by the adrenal glands, is a marker that is elevated in patients with psychological disorders, particularly anxiety. On the other hand, Temporomandibular Disorders (TMD) are a condition with a multifactorial etiology, in which emotional disturbances play a crucial role.

Therefore, the aim of this study is to evaluate whether patients with TMD have higher levels of salivary cortisol compared to the general population.

Initially, an assessment will be conducted using the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD) protocol to determine whether the patient suffer of any kind of Temporomandibular Disorder. Based on the results, individuals will be classified into two groups: the study group, consisting of patients with TMD, and the control group, composed of individuals without the disorder.

Those who agree to participate will be required to sign an informed consent form. Subsequently, a saliva sample will be collected for analysis.

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients who attend the dental clinic of the Faculty of Medicine of University of Coimbra

Exclusion criteria

• Pregnant women, minors and non-autonomous individuals

Trial design

50 participants in 1 patient group

Case group

Description:

Control group