Salivary Cortisol in Intensive Care Unit

Seoul National University

Status: Unknown

Conditions: Critically Ill

Treatments: Other: Salivary cortisol test

Study type: Observational

Funder types: Other

Identifiers

NCT02001207

H-1304-072-482

Details and patient eligibility

About

In critical illness, patients are highly stressed and should have elevated cortisol (stress hormone) secretion to adapt to stress. Dysfunction of this system is referred to as critical illness-related corticosteroid insufficiency. Free cortisol (unbound form) which is mainly responsible for its physiologic function is difficult to measure. We hypothesized that the salivary cortisol, which can be obtained by noninvasive methods, can more accurately evaluate adrenal function of critically ill patients.

Enrollment: 90 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients who agreed to participate

Exclusion criteria

• Known adrenal or pituitary disease
• oral bleeding
• currently on systemic or inhaled corticosteroids

Trial design

90 participants in 1 patient group

MICU patients

Treatment:

Other: Salivary cortisol test