Salivary Cystatin S Levels in a Group of Egyptian Children

Cairo University (CU)

Status: Active, not recruiting

Conditions: Early Childhood Caries

Treatments: Biological: Measurement of salivary cystatin S protein levels in saliva

Study type: Observational

Funder types: Other

Identifiers

NCT05716867

PEDO 1-2-1

Details and patient eligibility

About

Aim of the study

1. Measuring the levels of salivary cystatin S protein and salivary buffering capacity to determine their relation to early childhood caries.
2. Predection of early childhood caries by using salivary cystatin S levels with demographic, clinical and nutrition habits characteristics of the participants.

Enrollment: 30 estimated patients

Sex: All

Ages: 36 to 71 months old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Medically free children aged 36 to 71 months with one or more decayed (noncavitated or cavitated lesions), missing, or filled teeth due to caries in any primary tooth(cases).
• Medically free children aged 36 to 71 months with no decayed, missing, or filled teeth due to caries in any primary tooth(controls).

Exclusion criteria

• Children receiving antibiotic therapy within three month and fluoride prophylaxis within one year.
• Parents who will refuse to participate or refuse to sign the informed consent.
• Children who will not agree or cooperate with participation.

Trial design

30 participants in 2 patient groups

Children with early childhood caries aged between 36-71 month

Treatment:

Biological: Measurement of salivary cystatin S protein levels in saliva

Caries free children aged between 36-71 month

Treatment:

Biological: Measurement of salivary cystatin S protein levels in saliva