Salivary Gland Transplantation in the Treatment of Dry Eye in Patients With Stevens-Johnson Syndrome.

Federal University of São Paulo

Status: Completed

Conditions: Symblepharon; Dry Eye; Transplantation; Ocular Surface Disease

Treatments: Procedure: Salivary Gland and Labial Mucous Membrane Transplantation

Study type: Interventional

Funder types: Other

Identifiers

NCT01178242

0427/08

Details and patient eligibility

About

The purpose of this study is to evaluate salivary gland and labial mucous membrane transplantation in patients with severe symblepharon and dry eye secondary to Stevens-Johnson Syndrome (SJS).

Full description

This study was performed to evaluate the use of salivary gland and labial mucous membrane transplantation in patients with severe symblepharon and dry eye secondary to SJS. Labial mucous membrane and salivary gland transplantation showed to be a good option in the treatment of severe symblepharon and dry eye secondary to SJS. labial mucous membrane, salivary glands, symblepharon, entropion, transplantation, graft.

Enrollment: 19 patients

Sex: All

Ages: 10 to 58 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Only patients with poor visual acuity, less or equal to 20/200, and Schirmer I test equal to zero.
• Eyes with symblepharon or ankyloblepharon that did not allow the placement of a Schirmer test strip will be consider not measurable.

Exclusion criteria

• Active infection and corneal melting or perforation.

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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19 participants in 1 patient group

Salivary Gland and Labial Mucous Membrane Transplantation

Experimental group

Treatment:

Procedure: Salivary Gland and Labial Mucous Membrane Transplantation