Salivary LINC00657 as a Diagnostic Biomarker for Oral Squamous Cell Carcinoma

Fayoum University

Status: Completed

Conditions: Oral Squamous Cell Carcinoma

Study type: Observational

Funder types: Other

Identifiers

NCT05821179

M1

Details and patient eligibility

About

This study was designed to verify the role of salivary LINC00657 as a diagnostic marker in oral squamous cell carcinoma (OSCC) patients as compared to oral lichen planus (OLP) (as an example of oral potentially malignant lesions) and normal individuals, and to show its relation to miR-106a. A total of 36 participants were included.

Full description

This study was designed to verify the role of salivary LINC00657 as a diagnostic marker in oral squamous cell carcinoma (OSCC) patients as compared to oral lichen planus (OLP) (as an example of oral potentially malignant lesions) and normal individuals, and to show its relation to miR-106a. A total of 36 participants were included, subdivided into 3 groups: Group I: 12 patients diagnosed with OSCC. Group II: 12 patients diagnosed with OLP. Group III: 12 systemically free individuals with no oral mucosal lesions. statistical analysis and ROC analysis were performed

Enrollment: 36 patients

Sex: All

Ages: 20 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• group I : oral squamous cell carcinoma lesions (OSCC)
• group II: oral lichen planus lesions (OLP)
• group III: systemically healthy volunteers

Exclusion criteria

• oral lesions other than OSCC / OLP in group I and II
• any oral lesion in group III
• pregnant females

Trial design

36 participants in 3 patient groups

Group I

Description:

12 patients diagnosed with OSCC.

Group II

Description:

12 patients diagnosed with OLP.

Group III

Description:

12 systemically free individuals with no oral mucosal lesions.