Salivary Melatonin Levels and Sleep Quality in Patients With Burning Mouth Syndrome

University of Zagreb

Status: Completed

Conditions: Burning Mouth Syndrome; Melatonin

Treatments: Other: Epworth's sleepiness scale; unstimulated saliva sample

Study type: Observational

Funder types: Other

Identifiers

NCT05309681

09/2020

Details and patient eligibility

About

Burning mouth syndrome is an idiopathic condition characterized by symptoms burning and / or pain of the oral mucosa with an orderly clinical finding. So far not found a unique way of treatment. It is a diagnosis that impairs the quality of life of patients, and consequently it can affect the quality of sleep. Melatonin is a hormone secreted from pineal gland and regulates the day-night rhythm of man, and whose production in the body decreases aging. The level of melatonin in saliva correlates well with the level of melatonin in plasma, therefore they are advantages of determining from saliva painlessness and non-invasiveness of the procedure itself. The purpose of this study was to compare the level of melatonin in saliva and the quality of sleep with help of the Epworth Sleepiness Scale in patients with burning mouth syndrome and control groups of patients without subjective oral disorders and with an orderly clinical finding.

Enrollment: 45 patients

Sex: Female

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• female patients
• primary burning mouth syndrome
• without oral lesions

Exclusion criteria

• secondary burning mouth syndrome
• male gender
• patients with oral lesions

Trial design

45 participants in 2 patient groups

Study group

Description:

Female patients of the Department of Oral medicine diagnosed with burning mouth syndrome

Treatment:

Other: Epworth's sleepiness scale; unstimulated saliva sample

Control group

Description:

Age-matched female patients without oral lesions and without burning mouth syndrome

Treatment:

Other: Epworth's sleepiness scale; unstimulated saliva sample