Salivary Replication of BK Virus in Post-kidney Transplant (BKSAL)

Centre Hospitalier Universitaire, Amiens

Status: Not yet enrolling

Conditions: Nephropathy; Kidney Transplantation; BK Virus; DNAemia; Salivary Replication

Treatments: Biological: Salivary self-collection

Study type: Interventional

Funder types: Other

Identifiers

NCT07256470

PI2024_843_0093

Details and patient eligibility

About

BK virus infection in kidney transplantation can compromise graft function. Current data suggest that BK virus nephropathy results not only from transmission of virus from the donor but also from reactivation of latent virus in the recipient. However, no study has investigated the possibility of respiratory transmission. This study would provide a better understanding of the pathophysiology of BK virus infection in kidney transplant recipients. The investigators would study viral replication of BK virus in saliva, urine and blood of patients who received a kidney transplant at the Amiens University Hospital. For this, the investigators will collect salivary self-collection on the day of the kidney transplant then at 1, 3, 6, 9 and 12 months as well as a urine and blood sample. The investigators will measure BK viral load in these three samples at different times.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• kidney transplant recipients
• age ≥ 18 years

Exclusion criteria

• age < 18 years
• absence of consent

Trial design

Primary purpose: Screening

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)