Salt Loading and Thiazide Intervention Study (SALTI)

University of Maryland Baltimore (UMB)

Status and phase

Completed

Phase 4

Conditions

Hypertension

Treatments

Drug: Hydrochlorothiazide (HCTZ)

Procedure: Salt loading

Study type

Interventional

Funder types

Other

NIH

Identifiers

NCT00896389

R21DK084566 (U.S. NIH Grant/Contract)

HP-00040712

Details and patient eligibility

About

The investigators of this study propose to examine the relationships between STK39 (Serine Threonine Kinase 39) genotypes and responses to salt loading and to thiazide diuretics, hydrochlorothiazide. The investigators hypothesize that STK39 genotypes will be associated with the outcome of both interventions and can contribute to personalized care for hypertension.

Full description

Although hypertension can be easily diagnosed and there are many medications available to treat hypertension, this condition is poorly managed in many patients and is a leading cause of morbidity and mortality worldwide. Because a newly identified hypertension susceptibility gene, STK39 (Serine Threonine Kinase 39), plays a central role in kidney sodium transport, the investigators propose a pharmacogenetics study to examine the relationships between STK39 genotypes and blood pressure responses to salt loading and to thiazide diuretics, hydrochlorothiazide. In addition, STK39 genotypes may also predict those hypertension patients more likely to develop thiazide-induced hyperglycemia. The investigators hypothesize that STK39 genotypes of those single nucleotide polymorphisms (SNPs) that are associated with baseline systolic blood pressure (SBP), diastolic blood pressure (DBP), and hypertension status, will be associated with the outcome of both interventions. Therefore these SNPs can act as markers and contribute to personalized care for hypertension by identifying patients most likely to effectively control their blood pressure by adopting salt-reducing diet versus patients most likely to effectively and safely control their blood pressure by taking thiazide diuretics.

Enrollment

124 patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Old Order Amish
Age 18 to 65
Have systolic blood pressure between 120 and 160 and diastolic blood pressure between 80 and 100

Exclusion criteria

History of myocardial infarction, stroke, congestive heart failure, liver disease
Known cause of secondary hypertension
Diabetes or Fasting glucose > 100 mg/dL
Women who are pregnant, on oral contraceptives, or menstruating
Used hydrochlorothiazide (HCTZ) in the last 8 weeks or known allergy to HCTZ
Taking non-steroidal anti-inflammatory drugs
Estimated glomerular filtration rate < 80 mL/m
Intention to alter dietary habit during the study
Abuse of alcohol or drug