Salt Sensitivity, Cardiovascular and Metabolic Disease

Indiana University

Status: Completed

Conditions: Cerebrovascular Accident; Hypertension; Diabetes Mellitus; Heart Failure, Congestive; Angina Pectoris; Myocardial Infarction; Cardiovascular Diseases; Heart Failure; Heart Diseases

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT00005489

R01HL057826 (U.S. NIH Grant/Contract)

5005

Details and patient eligibility

About

To identify the role of salt-sensitivity of blood pressure in the pathogenesis of hypertension.

Full description

DESIGN NARRATIVE:

Approximately 498 of 750 normal and hypertensive subjects who were carefully characterized in terms of blood pressure response to salt loading and depletion in the late 1970s were re-examined to identify physiological factors contributing to salt-sensitivity of blood pressure. This helped to confirm preliminary observations suggesting that salt sensitivity in normotensive subjects predicted the subsequent development of hypertension with aging. In addition, longitudinal observations in hypertensive patients and in normotensives helped to determine whether salt-sensitivity or salt-resistance of blood pressure were associated with differences in the risk for development of specific forms of cardiovascular disease (stroke, angina, myocardial infarction, congestive heart failure), renal and metabolic (diabetes mellitus) disorders.

Sex: Male

Ages: Under 100 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

No eligibility criteria