Salvage Living Donor Liver Transplantation for HCC Beyond All Criteria Yield Equivalent Results to Milan Criteria

Ain Shams University

Status: Completed

Conditions: Hcc

Treatments: Procedure: living donor liver transplantation

Study type: Observational

Funder types: Other

Identifiers

NCT04069416

68954200

Details and patient eligibility

About

The present study aims to evaluate the impact of expanding criteria beyond Milan on tumor recurrence and patient survival that will help identify the best selection criteria for HCC transplanted patients.

Full description

Introduction:

HEPATOCELLULAR CARCINOMA (HCC) is the second leading cause of cancer mortality worldwide. Living donor liver transplantation (LDLT) for HCC patients has emerged as a rewarding therapy for a cure and a successful alternative where a Deceased donor liver transplantation (DDLT) program is lacking. Therefore, trials for careful expansion to Milan criteria have been adopted.

Aim of the study:

To evaluate the impact of expanding criteria beyond Milan on tumor recurrence and patient survival that will help identify the best selection criteria for HCC transplanted patients

Enrollment: 241 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patient transplanted for HCC eligible for transplant (no vascular invasion-no extra hepatic metastasis)
• age>18y

Exclusion criteria

• other etiology for liver transplant rather than HCC
• patient not fit for surgery
• age >70y

Trial design

241 participants in 3 patient groups

Group I

Description:

175 patients who fall within the Milan criteria.

Treatment:

Procedure: living donor liver transplantation

Group II

Description:

36 patients who fall within up-to-7 criteria

Treatment:

Procedure: living donor liver transplantation

Group III

Description:

30 patients beyond up-to-7 criteria and will be termed beyond all criteria (BAC).

Treatment:

Procedure: living donor liver transplantation