Salvage: Postconditioning With Adenosine for STEMI

University Hospital, Gasthuisberg

Status and phase

Unknown

Phase 2

Conditions

Acute ST Elevation Myocardial Infarction

Treatments

Drug: Adenosine

Study type

Interventional

Funder types

Other

Identifiers

NCT00284323

WD Salvage ML3181

Details and patient eligibility

About

Investigate the effect of selective intracoronary administration of adenosine on myocardial salvage and microvascular integrity in the setting of acute myocardial infarction.

Full description

Prospective, single center, randomized clinical study. Study design is random patient assignment to selective intracoronary administration of adenosine or control immediately before restoration of coronary artery patency in patients presenting with an acute ST segment-elevation myocardial infarction (STEMI). Randomisation will be stratified for the duration of symptoms (< 4 hours vs > 4 hours).

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

Myocardial infarction of less than 12 hours duration with symptoms lasting at least 20 minutes.
ECG-criteria: ST-segment elevation of > 0.1 mV in 2 or more limb leads or > 0.2 mV in 2 or more contiguous precordial leads or presumed new left bundle branch block.
Written informed consent prior to inclusion in the study. If this is not possible, verbal informed consent from the patient or written assent of a legally acceptable representative should be obtained, to be followed by written informed consent by the patient at the earliest subsequent opportunity.
Adequate vascular access seems possible (femoral pulsation palpable).

Exclusion criteria

Contra-indication to heparin, LMWH, clopidogrel.
Anticipated difficulty with vascular access.
Cardiogenic shock.
Inability to give informed consent (or assent).
High grade atrioventricular block; severe asthma; treatment with theophylline, glibenclamide (Diamicron) or dipyridamole.
Prior CABG.
Participation in an investigational drug or device study within the past 30 days.