Sarcopenia and Cirrhosis

Rigshospitalet

Status: Completed

Conditions: Cirrhosis

Treatments: Dietary Supplement: Amino acid infusion; Other: Bloodsamples, Biopsies.

Study type: Interventional

Funder types: Other

Identifiers

NCT02132962

H-4-2012-162

Details and patient eligibility

About

The study investigates the effect of aminoacid infusion on proteinturnover in muscle from cirrhosis subjects, compared to healthy controls.

The hypothesis is that aminoacid infusion can attenuate the increase in proteindegradation that follows cirrhosis.

Enrollment: 17 patients

Sex: Male

Ages: 30 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Male subjects
• Diagnosis of cirrhosis, Child-Pugh A, B, C.

Exclusion criteria

• Acute illness within 3 weeks
• Ascites collections within 10 days
• Heart-, kidney, pulmonary disease. Cancer. Type 1 diabetes.
• Active alkoholdrinking

Trial design

Primary purpose: Basic Science

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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17 participants in 2 patient groups

Healthy controls

Active Comparator group

Description:

Amino acid infusion

Treatment:

Other: Bloodsamples, Biopsies.

Dietary Supplement: Amino acid infusion

Cirrhosis

Active Comparator group

Description:

Amino acid infusion

Treatment:

Other: Bloodsamples, Biopsies.

Dietary Supplement: Amino acid infusion