Sarcopenia and Osteoporosis in the Patients With Hemophilia

Tri-Service General Hospital

Status: Completed

Conditions: Osteoporosis, Osteopenia; Hemophilic Arthropathy; Sarcopenia; Hemophilia

Treatments: Diagnostic Test: Dual-energy X-ray absorptiometry (DXA)

Study type: Observational

Funder types: Other

Identifiers

NCT04535180

1-107-05-053

Details and patient eligibility

About

Hemophilia is a bleeding disorder and repeated joint bleeding leads to hemophilic arthropathy. Among patients with hemophilia, vitamin D deficiency and hemophilic arthropathy have been associated with osteoporosis in several clinical studies.There is no data on the prevalence of osteoporosis in hemophilia patients in Taiwan or Asia. To the best of our knowledge, no previous studies have reported the prevalence of sarcopenia and correlation with osteoporosis in hemophilia adult patients. This study will investigate the prevalence and corelation of sarcopenia and low BMD in patients with hemophilia.

patients in Taiwan. The study will estimate the prevalence of sarcopenia and body composition in the hemophilia population and compared baseline demographic and clinical characteristics between the non-sarcopenia and sarcopenia individuals, with particular emphasis on the overlap with osteoporosis and hemophilic arthropathy.

Enrollment: 45 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Hemophilia patients

Exclusion criteria

• History of total hip arthroplasty
• History of instrumentation in lumbar spine

Trial design

45 participants in 1 patient group

Hemophilia

Treatment:

Diagnostic Test: Dual-energy X-ray absorptiometry (DXA)