Sarcopenia and Peripheral Artery Disease With Chronic Limb Threatening Ischemia (SAC)

Fudan University

Status: Completed

Conditions: Chronic Limb Threatening Ischemia; Peripheral Arterial Disease; Sarcopenia

Treatments: Other: Not applicable- observational study

Study type: Observational

Funder types: Other

Identifiers

NCT07037979

2025ZW02

Details and patient eligibility

About

To evaluate the correlation of Sarcopenia Parameters and Peripheral Artery Disease with chronic limb threatening ischaemia.

Full description

Prior researches indicated a relatively high prevalence of sarcopenia among patients of Peripheral Artery Disease. However, the relationship between sarcopenia and progression of Peripheral Artery Disease with chronic limb threatening ischaemia remained poorly understood. Thus, this cohort study aimed to evaluate the correlation of Sarcopenia Parameters, such as psoas muscle area (PMA) and total abdominal muscle area (TAMA) at the L3 vertebral level, measured by computed tomography (CT), and progression of Peripheral Artery Disease with chronic limb threatening ischaemia.

Enrollment: 97 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients of Peripheral Artery Disease, including intermittent claudication and Chronic Limb Threatening Ischemia;
• Patients with Rutherford grade 2-6 between Jan.1 2023 and Dec.31 2024;
• Patients at age 18-80;
• Patients underwent an in-hospital routine enhanced whole abdomen to lower extremities CT scan;
• Patients able to complete the clinical follow-up for 3 months.

Exclusion criteria

• Poor CT quality or incomplete images;
• Incomplete clinical data;
• In-hospital mortality during Jan.1 2023 and Dec.31 2024.

Trial design

97 participants in 1 patient group

patiets with peripheral artery disease

Treatment:

Other: Not applicable- observational study