Sarcopenia in Patients With Idiopathic Pulmonary Fibrosis

Mersin University

Status: Completed

Conditions: Idiopathic Pulmonary Fibrosis (IPF); Sarcopenia

Study type: Observational

Funder types: Other

Identifiers

NCT07178197

2022/736

Details and patient eligibility

About

Sarcopenia negatively affects the prognosis of chronic diseases. However, the importance of sarcopenia in patients with idiopathic pulmonary fibrosis (IPF) has been less emphasized. The aim of the study is to determine the prevalence of sarcopenia in patients with IPF and to evaluate the impact of sarcopenia on quality of life and disease progression.

This study was designed as a descriptive cross-sectional. The study included patients diagnosed with IPF. Hand dynamometry and bioelectrical impedance analysis (BIA) were used to for diagnose of sarcopenia. Pulmonary function tests, maximal inspiratory pressure (MIP), and maximal expiratory pressure (MEP) measurements were examined. The 6-minute walk distance (6MWD) and 4-meter walking speed were recorded. The St. George Respiratory Questionnaire (SGRQ) was used to assess quality of life. All patients were evaluated for progressive disease.

Full description

The study was designed as a cross-sectional study.

Enrollment: 60 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Being over 18 years of age
• Signing the informed consent form
• Having a diagnosis of IPF for at least one month

Exclusion criteria

• Pregnancy
• History of cancer within the last 5 years
• History of lung surgery
• History of neuromuscular disease
• Active pulmonary tuberculosis
• Active respiratory tract infection
• Inability to perform pulmonary function tests
• Presence of a pacemaker
• History of systemic steroid use within the past 3 months
• Inability to use a hand dynamometer

Trial design

60 participants in 1 patient group

idiopathic pulmonary fibrosis (IPF)

Description:

The prevalence of sarcopenia was investigated in patients with IPF who met the inclusion and exclusion criteria. The relationship between sarcopenia and quality of life and disease progression in patients with IPF was evaluated.