SArcopenia Prevalence in Frail Older Adults. SAF Study

Toulouse University Hospital

Status: Completed

Conditions: Aging

Treatments: Radiation: Dual-energy X-ray absorptiometry (DXA)

Study type: Interventional

Funder types: Other

Identifiers

NCT02903992

2016-A00181-50 (Other Identifier)

RC31/15/7817

Details and patient eligibility

About

The age-associated loss of lean mass is a defining parameter of sarcopenia and may lead to various negative health outcomes such as impairment of physical performance and disability. Furthermore sarcopenia is considered to be one of the main factors in the pathogenesis of the frailty syndrome. However, for clinical use and for treatment and prevention strategies, reliable diagnostic criteria and cutpoints based on clinically relevant thresholds are indispensable.

This topic has recently been addressed by the Foundation for the National Institutes of Health Sarcopenia Project which identified cutpoints for appendicular lean mass (ALM) below which older adults had a higher likelihood of clinically relevant weakness reflected by low grip strength. Moreover, a low ALM-to-body mass index (BMI) ratio (<0.789 men and <0.512 women) was found to be associated with increased likelihood for mobility impairment.

In this context, the aim of this study is to study the prevalence of sarcopenia in a sample of community-dwelling frail and pre-frail older adults.

Enrollment: 225 patients

Sex: All

Ages: 70+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged 70 years and over,
• Living independently (ADL score ≥ 5/6),
• Fail or pre-frail according to Fried criteria,
• Informed written consent,
• Subjects affiliated to a social security.

Exclusion criteria

• Robusts patients (no Fried criteria),
• Other disorders that could interfere with the interpretation of the study (like visual or hearing impairments),
• Subjects under justice protection,
• Participation in another study at the same time.

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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225 participants in 1 patient group

All patients recruited

Other group

Description:

All patients who are enrolled in study with at least one Fried criteria will have a Dual-energy X-ray absorptiometry (DXA) to measure lean muscle mass adjusted for body mass index. As part of the usual care in the Frailty Clinic patients will also have a clinical examination, a standard biological sample (requiring 15 ml of blood); an evaluation of the cognitive and functional performances, of their medico-economic situation and lifestyle.

Treatment:

Radiation: Dual-energy X-ray absorptiometry (DXA)