Satiety Effects on the Neural Valuation of Food

Duke University

Status: Completed

Conditions: Fed; Fasting

Study type: Observational

Funder types: Other

Identifiers

NCT01721187

VOFIO3G

Details and patient eligibility

About

Using fMRI, this study will explore the neural correlates of satiety when individuals make decisions about food. The investigators will also examine individual differences in satiety effects.

Enrollment: 60 patients

Sex: All

Ages: 21 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Chinese ethnicity
• 21 to 45 years old
• English as first language
• Right-handed
• Have normal eyesight, or have long-sightedness or myopia within +8.0 to -8.0 diopters (unless corrected by contact lenses)
• Weigh less than 100kg with an abdominal circumference of less than 120cm
• Non-smoker, or only smoke occasionally (less than 5 sticks a week)
• Consume less than 2 units (200 mg) of caffeine a day
• Consume less than 21 units of alcohol per week (e.g. 500ml 5% beer = 2.5 units, 250ml 14% wine = 3.5 unit)
• Habitually sleep before 1am and wake before 9am

Exclusion criteria

• On a restrictive diet (e.g., vegetarian/vegan diet)
• History of food allergies
• History of psychiatric or neurological disorders
• History of chronic medical illness
• Metal implants in or on the body (e.g. braces, dental retainers, pacemakers)
• Shift worker
• Claustrophobic
• High astigmatism (high = >2.00 diopters)
• Colour-blind

Trial design

60 participants in 2 patient groups

Low disinhibition

Description:

fMRI during fed and fasted states

High disinhibition

Description:

fMRI during fed and fasted states