Satiety, Glycemic, and Gastrointestinal Effects of Novel Fibers

University of Minnesota (UMN)

Status: Completed

Conditions: Healthy

Treatments: Dietary Supplement: Placebo; Dietary Supplement: Fiber made from corn starch; Dietary Supplement: Resistant starch + soluble fiber; Dietary Supplement: Fiber made from corn starch + soluble fiber; Dietary Supplement: Resistant Starch

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT00958399

0701M00264

Details and patient eligibility

About

Research suggests dietary fiber may play a role in weight management, and fiber consumption is inversely associated with body weight, body fat, and BMI in cross-sectional studies. These effects may be mediated by increased satiety, reduced food intake, or changes in blood levels of glucose, insulin, and gut hormones.

The purpose of this study is to determine the satiety, glycemic, hormonal, and gastrointestinal responses of novel fiber supplements.

Enrollment: 20 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy men and women
• age 18-60 years
• non-smoking
• not taking medication
• non-dieting (weight stable in prior 3 months)
• BMI 18-27
• English literacy
• ability to give blood

Exclusion criteria

• do not regularly consume breakfast
• food allergies to ingredients found in study products
• dislike for muffins, fiber bars, or hot cereal
• BMI <18 or >27
• diagnosed cardiovascular, renal, or hepatic disease
• diabetes mellitus (fasting blood sugar >126 mg/dl)
• cancer in previous 5 years (except basal cell carcinoma of the skin)
• any gastrointestinal disease or condition
• recent bacterial infection (< 3 months)
• recent or concurrent participation in an intervention research study
• history of drug or alcohol abuse in prior 6 months
• use of lipid-lowering, anti-hypertensive, or anti-inflammatory steroid medication
• restrained eaters
• vegetarians
• people who eat more than approximately 15 grams of fiber per day
• women who are pregnant or lactating
• women with irregular menstrual cycles

Trial design

20 participants in 5 patient groups, including a placebo group

No fiber

Placebo Comparator group

Description:

No fiber added to study products

Treatment:

Dietary Supplement: Placebo

Resistant Starch

Experimental group

Description:

Muffins, cereal, and bars made with a resistant starch

Treatment:

Dietary Supplement: Resistant Starch

Resistant starch + soluble fiber

Experimental group

Description:

Muffins, cereal, and bars made with a mixture of resistant starch and a soluble fiber

Treatment:

Dietary Supplement: Resistant starch + soluble fiber

Fiber made from corn starch

Experimental group

Description:

Muffins, cereal, and bars made with novel corn fiber

Treatment:

Dietary Supplement: Fiber made from corn starch

Fiber made from corn starch + soluble fiber

Experimental group

Description:

Muffins, cereal, and bars made with a mixture of novel corn fiber and a soluble fiber

Treatment:

Dietary Supplement: Fiber made from corn starch + soluble fiber