Satiety, Meal Frequency and Nutritional Aspects (SAFRAN)

Civil Hospices of Lyon

Status

Terminated

Conditions

Volunteers

Treatments

Other: Increasing eating frequency

Study type

Interventional

Funder types

Other

Identifiers

NCT01573988

2010.612/16

Details and patient eligibility

About

In this study, the investigators are interested in assessing the effects of the isocaloric increase of eating frequency on appetite and metabolism. How the consumption of an isocaloric breakfast in four intakes vs. one can modify satiety and appetite control in lean and obese subjects through :

the physiological consequences : difference in postprandial kinetics of glucose, non esterified fatty acid, triglyceride, the secretion of satiety gut hormone (insulin, ghrelin, leptin and cholescystokinine (CCK), peptide YY (PYY), glucagon-like peptide-1 (GLP-1), nutrients oxidative fate and plasmatic oxidative stress (Malondialdehyde (MDA), glutathion, lipid hydroperoxides)
eating behavior during an ad libitum buffet test meal

Enrollment

37 patients

Sex

Male

Ages

20 to 40 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

No smokers
BMI 20 to 35 kg/m2
Moderate physical activity
Safety during medical consultation
Feeding behavioural phenotype (Dutch Eating Questionnaire, Three Eating Factor Questionnaire)

Exclusion criteria

Medical history which may affect glucose metabolism (diabetes, renal or hepatic failure, thyroid dysfunction, Cushing syndrome, acromegaly...)
Medical history which affect nutrient absorption (gastro-intestinal and pancreatic disease, gastrectomy, colectomy...)
Drug use in the last two months that could affect glucose metabolism (steroids, topical gastric preparation, anorectic drugs...)
Eating disorders
Claustrophobic subjects