Satiety Response of Four Dietary Fibers

University of Minnesota (UMN)

Status and phase: Completed; Early Phase 1

Conditions: Healthy

Treatments: Dietary Supplement: Soluble corn fiber; Dietary Supplement: Control; Dietary Supplement: Fructooligosaccharide; Dietary Supplement: Resistant starch; Dietary Supplement: Inulin

Study type: Interventional

Funder types: Other

Identifiers

NCT01233024

1003E78714

Details and patient eligibility

About

Studies have found a relationship between dietary fiber consumption and body weight regulation. This relationship may stem from enhanced satiety through fermentation of certain fibers in the large intestine.

The objective of this study is to determine and compare satiety ratings, changes in food intake, and gastrointestinal effects for four fibers: fructooligosaccharide, inulin, soluble corn fiber, and resistant starch.

Enrollment: 20 patients

Sex: Female

Ages: 18 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy women
• Age 18-40 years
• Nonsmoking
• Not taking weight loss medications
• Non-dieting (weight has not changed more than 11 pounds over three months)
• BMI between 18.5 and 29
• Spoken and written English literacy

Exclusion criteria

• Do not regularly consume breakfast
• Food allergies to wheat, soy, peanut, or dairy
• BMI less than 25 or greater than 29 upon admission to study
• Cancer diagnosis in past 5 years
• History of heart disease, kidney disease, diabetes, or eating disorder
• History of ulcerative colitis, Crohn's disease, or any other gastrointestinal condition
• History of drug or alcohol abuse in past 6 months
• Use of lipid-lowering, anti-hypertensive, or anti-inflammatory steroid medication
• Concurrent or recent (within 30 days) intervention study participation
• Pregnant or lactating
• Irregular menstrual cycle
• Vegetarians
• People who eat more than approximately 15 grams of fiber per day

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Triple Blind

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20 participants in 5 patient groups, including a placebo group

Low fiber control

Placebo Comparator group

Description:

no treatment dinner bar, no treatment breakfast bar

Treatment:

Dietary Supplement: Control

Promitor soluble corn fiber

Experimental group

Description:

12g in dinner bar, 11g in breakfast bar

Treatment:

Dietary Supplement: Soluble corn fiber

FiberSym resistant starch

Experimental group

Description:

12g in dinner bar, 11g breakfast bar

Treatment:

Dietary Supplement: Resistant starch

Orafti P95 fructooligosaccharide

Experimental group

Description:

12g in dinner bar, 11g in breakfast bar

Treatment:

Dietary Supplement: Fructooligosaccharide

Orafti HPX inulin

Experimental group

Description:

12g in dinner bar, 11g in breakfast bar

Treatment:

Dietary Supplement: Inulin