Savolitinib Plus Osimertinib Versus Platinum-based Doublet Chemotherapy in Participants With Non-Small Cell Lung Cancer Who Have Progressed on Osimertinib Treatment (SAFFRON)

AstraZeneca

Status and phase

Enrolling

Phase 3

Conditions

Non-Small-Cell Lung

Carcinoma

Treatments

Drug: Osimertinib

Drug: Pemetrexed

Drug: Carboplatin

Drug: Savolitinib

Drug: Cisplatin

Study type

Interventional

Funder types

Industry

Identifiers

NCT05261399

2021-006374-24 (EudraCT Number)

D5087C00001

2024-511169-12-00 (Other Identifier)

Details and patient eligibility

About

Clinical study to investigate the efficacy and safety of savolitinib in combination with osimertinib versus platinum-based doublet chemotherapy in participants with EGFR mutated, MET-overexpressed and/or amplified, locally advanced or metastatic NSCLC who have progressed on treatment with Osimertinib.

Full description

This is a multicentre, Phase III, randomised, open-label study to investigate the efficacy and safety of savolitinib administered orally in combination with osimertinib versus platinum-based doublet chemotherapy in participants with EGFR mutated, MET-overexpressed and/or amplified, locally advanced or metastatic NSCLC who have progressed on first- or second-line treatment with osimertinib as the most recent therapy.

Approximately 324 participants with EGFR mutated, MET-overexpressed and/or amplified, locally advanced or metastatic NSCLC will be randomly assigned to study intervention with 1:1 ratio.

Patients will be treated until either objective progression of disease (PD) by Response Evaluation Criteria in Solid Tumours 1.1 (RECIST 1.1) is assessed by the investigator, unacceptable toxicity occurs, consent is withdrawn, or another discontinuation criterion is met.

Enrollment

324 estimated patients

Sex

All

Ages

18 to 130 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Provision of signed and dated written ICF prior to any mandatory and non-mandatory study-specific procedures, sampling and analyses.
Participant must be ≥18 years (≥ 19 years of age in South Korea) at the time of signing the informed consent. All genders are permitted.
Histologically or cytologically confirmed locally advanced or metastatic NSCLC which is not amenable to curative therapy.
Must have at least one documented sensitising EGFR mutation: exon19 deletion, L858R mutation, and/or T790M.
Documented radiologic progression on first- or second-line treatment with osimertinib as the most recent anti-cancer therapy.
Mandatory provision of FFPE tumour tissue.
MET overexpression and/or amplification in tumour specimen collected following progression on prior osimertinib treatment.
Measurable disease as defined by RECIST 1.1.
Adequate haematological, liver, renal and cardiac functions, and coagulation parameters.
ECOG performance status of 0 or 1.

Exclusion criteria

Predominant squamous NSCLC, and small cell lung cancer.
Prior or current treatment with a third-generation EGFR-TKI other than Osimertinib.
Prior or current treatment with savolitinib or another MET inhibitors.
Spinal cord compression or brain metastases, unless asymptomatic and are stable.
History or active leptomeningeal carcinomatosis.
Unresolved toxicities from any prior therapy greater than CTCAE Grade 1 and prior platinum-therapy related Grade 2 neuropathies with the exception of alopecia and haemoglobin ≥ 9.0 g/dL.
Active/unstable cardiac diseases currently or within the last 6 months, clinically significant ECG abnormalities, and/or factors/medications that may affect QTc intervals.
History of liver cirrhosis of any origin and clinical stage; or history of other serious liver disease or chronic disease with relevant liver involvement.
Known serious active infection including, but not limited to, tuberculosis, or HIV, HBV or HCV or gastrointestinal disease.
Receipt of live attenuated vaccine (including against COVID-19) within 30 days prior to the first dose of study intervention.
Past medical history of ILD, drug-induced ILD, radiation pneumonitis, which required steroid treatment, or any evidence of clinically active ILD.
Participants currently receiving medications or herbal supplements known to be strong inducers of cytochrome P450 (CYP)3A4 or strong inhibitors of CYP1A2.

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

324 participants in 2 patient groups

Chemotherapy

Active Comparator group

Description:

Pemetrexed (500 mg/m2) with either cisplatin (75 mg/m2) or carboplatin (AUC5) on Day 1 of 21-day cycles (Q3W) for 4 cycles, followed by pemetrexed maintenance (500 mg/m2) Q3W

Treatment: