SBU-RESET: RElaxation, Stress Reduction and Epigenetics Trial in Cancer Survivors

Barbara Nemesure

Status: Enrolling

Conditions: Lung Adenocarcinoma Stage IIIB/IV; Lung Adenocarcinoma Stage IV; Lung Adenocarcinoma Metastatic; Lung Adenocarcinoma Stage I; NHL; Lung Adenocarcinoma Stage II; Colon Cancer; Lung Cancer (Diagnosis); Lung Adenocarcinoma Stage III; Lung Adenocarcinoma; NHL - Non-Hodgkin&Amp;#39;s Lymphoma

Treatments: Behavioral: Oncology-informed yoga; Behavioral: SMART

Study type: Interventional

Funder types: Other

Identifiers

NCT07161713

SBU-RESET

IRB2025-00282 (Other Identifier)

Details and patient eligibility

About

Cancer survivors can experience health issues that cause chronic illness and lower quality of life. Yoga is a well-known holistic approach to health and overall well-being. Mindfulness has many benefits, including improved focus and less stress. This study aims to evaluate if yoga and/or mindfulness has a positive effect on cancer survivors social, emotional and physical well-being as well as their epigenetics. Epigenetics is how the environment can effect your genes; not by changing our DNA, but by turning genes on or off.

Full description

Randomized interventional pilot study to evaluate whether a mind-body intervention (Stress Management and Resiliency Training (SMART) or (oncology-informed yoga) influences patient-reported Quality of life (QoL) outcomes (physical/social/emotional/ functional well-being and symptom burden) in Lung Colon, and Non-Hodgkin's lymphoma (NHL) survivors. A secondary (exploratory) aim is to evaluate whether these mind-body interventions impact epigenetics.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults over 18 years old
• Primary diagnosis: Lung Cancer, Colon Cancer and Non-Hodgkin's lymphoma (NHL)
• Six months post cancer-directed treatment (chemotherapy, targeted and immunotherapy). Patients with active disease (e.g. metastatic colorectal cancer) who are not receiving any cancer-directed treatment are eligible.
• Able to provide a saliva sample
• Gives informed consent and agrees to be randomly assigned
• Able to complete the questionnaire(s) in English.

Exclusion criteria

• Adults with primary anal and/or primary rectal cancer.
• Adult cancer survivors who are currently on an active treatment regimen.
• Oral or any pathological conditions that can limit the ability to produce saliva.
• Unable to participate in full length study period and follow up thereafter.
• Is pregnant or plan to become pregnant during the study period.
• Currently practicing yoga or SMART
• Those on corticosteroid therapy.
• Documented fall or syncope within the last 6 months

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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100 participants in 2 patient groups

Yoga

Experimental group

Description:

Oncology-informed yoga

Treatment:

Behavioral: Oncology-informed yoga

SMART

Experimental group

Description:

Stress Management and Resiliency Training

Treatment:

Behavioral: SMART