Scalp Care Efficacy Evaluation for Premium Scalp Revitalizing Essence

Hungkuang University

Status: Completed

Conditions: Hair Loss; Scalp Health; Sebum Production; Hair Condition; Hair and Scalp Health

Treatments: Other: Base formula plus Centella asiatica extracellular vesicles; Other: Placebo control; Other: Base formula plus Centella asiatica extracellular vesicles, IGF-1 & FGF-7; Other: Base formula plus IGF-1 and FGF-7; Other: Base formula only

Study type: Interventional

Funder types: Other

Identifiers

NCT06985121

25-016-A

Details and patient eligibility

About

The study aims to evaluate the efficacy of the Premium Scalp Revitalizing Essence on human scalp skin. A total of 60 healthy adults, aged 18 to 60, will be recruited and randomly assigned into five groups receiving different formulations. Participants will use the product once daily for 56 days, and their scalp conditions will be assessed through skin texture tests at multiple time points. Key parameters such as sebum content, overall hair loss, hair density, scalp condition, and hair length will be measured.

Full description

This is a prospective, randomized, double-blinded, and placebo-controlled study to investigate the effects of Premium Scalp Revitalizing Essence on changes in the skin texture of human scalp skin.

Sixty healthy adults aged from 18 to 60 will be recruited and randomly assigned into five groups, with 12 individuals in each group. Group 1 uses Placebo (Base formula without caffeine and panthenol); Group 2 uses the Base formula (Control with caffeine and panthenol); Group 3 uses Base + IGF-1 & FGF-7; Group 4 uses Base + Centella asiatica extracellular vesicles; Group 5 uses Base + Centella Asiatica Exosome + IGF-1 & FGF-7. Before using the test product, all 60 participants undergo the first scalp skin texture test. After 14 days of using the test product, a second scalp skin texture test is conducted; after 28 days of use, a third test is performed; after 42 days of use, a fourth test is conducted; and after 56 days of use, a fifth test is carried out. The scalp skin texture tests include measurements of skin (1) sebum content, (2) overall hair loss, (3) hair density, (4) scalp condition, (5) hair length, and other parameters. The Sebumeter® SM815 probe of the MPA580 device and the ScalpX Intelligent Scalp Diagnostic System will be used to measure the parameters of the study.

Enrollment: 60 patients

Sex: All

Ages: 16 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy adults of any gender from the age of 18 to 60 years (inclusive).
• Absence of chronic diseases, major illnesses, or allergies.
• Major illnesses include cancer, post-stroke disorders, paralysis, acute myocardial infarction, coro-nary artery bypass surgery, end-stage renal disease, and major organ transplant or hematopoietic stem cell transplant

Exclusion criteria

• Currently taking any medication or using any scalp care products

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

---

60 participants in 5 patient groups, including a placebo group

Group 1: Placebo control

Placebo Comparator group

Description:

Base formula without caffeine and panthenol

Treatment:

Other: Placebo control

Group 2: Base formula only

Experimental group

Description:

Base formula consisting of active ingredients caffeine and panthenol (vitamin B5).

Treatment:

Other: Base formula only

Group 3: Base formula plus IGF-1 & FGF-7.

Experimental group

Description:

Base formula plus insulin growth factor 1 (IGF-1) and fibroblast growth factor-7 (FGF-7)

Treatment:

Other: Base formula plus IGF-1 and FGF-7

Base formula plus Centella asiatica extracellular vesicles

Experimental group

Description:

Base formula plus Centella asiatica extracellular vesicles

Treatment:

Other: Base formula plus Centella asiatica extracellular vesicles

Group 5: Base formula plus Centella asiatica extracellular vesicles, IGF-1 & FGF-7.

Experimental group

Description:

Base formula plus Centella asiatica extracellular vesicles, insulin growth factor-1 (IGF-1) and fibroblast growth factor-7 (FGF-7).

Treatment:

Other: Base formula plus Centella asiatica extracellular vesicles, IGF-1 & FGF-7