Schizophrenia, Antipsychotic Treatment and the Risk for Diabetes Mellitus

University of Pittsburgh

Status: Completed

Conditions: Schizophrenia; Schizoaffective Disorder; Delusional Disorder

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT00222807

0306110

Details and patient eligibility

About

This preliminary study aims to investigate the mechanism of higher rates of type 2 diabetes mellitus in patients with schizophrenia. As part of the study, we collect neuroendocrine-immune data on patients with first episode, treatment naive psychosis, patients with newly diagnosed schizophrenia and normal healthy controls.

Regardless the treatment status, we collect the same neuroendocrine-immune data on the participants after 2 months.

Full description

This preliminary study aims to investigate the mechanism of higher rates of type 2 diabetes mellitus in patients with schizophrenia. As part of the study, we collect neuroendocrine-immune data on patients with first episode, treatment naive psychosis, patients with newly diagnosed schizophrenia and normal healthy controls.

Regardless the treatment status, we collect the same neuroendocrine-immune on the participants (patients and controls) after 2 months. Thus, our study does not control treatment. Patients take treatment in consultation with their physician. Some of them even decide not to take any medications. At the 2nd visit, we do ask them about the the medications they are taking if any.

Enrollment: 200 patients

Sex: All

Ages: 14 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Psychotic disorder as per DSM-IV criteria of the American Psychiatric Association

Exclusion criteria

• Diabetes, type 1 or 2
• Prominent substance abuse (i.e. psychotic symptoms attributable entirely to substance use)
• Age above 50 or age below 14