Schizophrenia Imaging

Tel Aviv Sourasky Medical Center

Status: Unknown

Conditions: Foetal Differences Between Healthy and Schizophernic Parents

Treatments: Device: imaging follow up: MRI scan; Device: imaging follow up: Ultrasonographic examination

Study type: Interventional

Funder types: Other

Identifiers

NCT01655472

18105 (Other Grant/Funding Number)

TASMC-11-NR-0192-11-CTIL

Details and patient eligibility

About

Schizophrenia is a common disorder with a lifetime prevalence of about 1%.Genetic studies strongly suggest a genetic component to the inheritance of schizophrenia. Structural neuroimaging studies have provided consistent evidence for brain abnormalities in schizophrenia. The timing of brain abnormalities in schizophrenia has not been determined yet.

The investigators hypothesize that brain structural changes can be detected in neonatal life. The investigators hypothesize that offspring of schizophrenic patients will have higher rates of brain structural changes in the neonatal period. The investigators propose to study early development of fetuses in offspring of patients with schizophrenia. The study is a multi-center prospective trial.

Enrollment: 80 estimated patients

Sex: Female

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Pregnant women who carry an offspring of a schizophrenia patient: whether the mother, the father or both suffer from schizophrenia.

Exclusion criteria

• Alcohol or drug abuse of pregnant woman
• Past history or present occurrence of major neurologic or somatic illness
• Genetic disease
• Other psychiatric disorders other than schizophrenia such as Mental retardation
• Bipolar Disorder and Delusional Disorder

Trial design

Primary purpose: Screening

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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80 participants in 2 patient groups

healthy parents

Active Comparator group

Treatment:

Device: imaging follow up: MRI scan

Device: imaging follow up: Ultrasonographic examination

schizophrenic parents

Active Comparator group

Treatment:

Device: imaging follow up: MRI scan

Device: imaging follow up: Ultrasonographic examination