Sciatic Nerve Stiffness Using Two-Sequences of Lower Limb Neurodynamic Testing: A Shear Wave Elastography Study

Cairo University (CU)

Status: Enrolling

Conditions: Sciatic Nerve

Treatments: Diagnostic Test: Lower Limb Neurodynamic Test (LLNT) with Shear Wave Elastography

Study type: Observational

Funder types: Other

Identifiers

NCT07136441

P.T.REC/012/005897

Details and patient eligibility

About

The purposes of the study are:

1. To measure differences in Sciatic nerve (SN) stiffness using shear-wave elastography (SWE) during two movement sequences of the lower limb neurodynamic test (LLNT) in low back pain with sciatica.
2. To measure differences in Sciatic nerve stiffness using shear-wave elastography during two movement sequences of the lower limb neurodynamic test in control group.
3. To compare difference in Sciatic nerve stiffness using shear-wave elastography during two movement sequences of the lower limb neurodynamic test between low back pain patients with sciatica and control group.

Full description

As peripheral nerves can exhibit regional variations in their anatomy and mechanical properties, investigating the response of different nerve segments to different loading patterns based on the order of joint movement will provide a better understanding of nerve biomechanics during neurodynamic testing.

This may help optimize the lower limb neurodynamic test (LLNT) application for different pathological situations and potentially increase its diagnostic capacity to detect localized alterations in a specific nerve segment such as sciatica.

Ultrasonography does not have the sensitivity required to detect all forms of peripheral nerve disorders and fails to provide information about nerve mechanical properties such as stiffness.

By using neurodynamic sequencing, clinicians may direct neural stress toward targeted areas suspected of involvement and, at the same time, perform the test with reduced load on more remote nerve segments. The ability to modify neural load distribution during the LLNT could play an interesting role in differential diagnosis, when symptoms present similar characteristics but have different regional origin.

There is a gap in the literature concerning the measurement of (SWV) of sciatic nerve during LLNT proximal (LLNT-PROX) to distal and from distal (LLNT_DIST) to proximal sequences of LLNT.

Enrollment: 60 estimated patients

Sex: All

Ages: 25 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Thirty participants ranging in age from 25 to 40 years from both genders with a diagnosis of low back pain with radiating leg pain and thirty control group.
• The main symptoms are low back pain with unilateral leg pain(sciatica) for 3-12 months for group A.
• Patients with lumbar disc herniation (L4-5) with diagnostic imaging as MRI for group A.
• Positive straight leg raising are considered for inclusion in the study for group A.
• Control group must be free from any symptoms of nerve irritation or compression, with normal neurological examination findings, including reflexes, sensation, negative straight leg raising and motor strength.

Exclusion criteria

• Diabetes mellitus.
• Any type of polyneuropathy
• Trauma of lumbar spine
• Previous history of back surgery
• Piriformis syndrome.
• Participants with conditions that reduce image quality on US imaging (thick gluteal subcutaneous fat tissue.
• Hip joint prosthesis.
• Professional athletes (Neto et al., 2024).
• Skin infection

Trial design

60 participants in 2 patient groups

Group A (Low Back Pain with Sciatica)

Description:

Thirty patients with low back pain with sciatica aged 25-40 years with unilateral leg pain for 3-12 months, lumbar disc herniation (L4-5) confirmed by MRI, and positive straight leg raising test. Participants will receive sciatic nerve tension tests using both proximal-to-distal and distal-to-proximal sequences with shear wave elastography assessment.

Treatment:

Diagnostic Test: Lower Limb Neurodynamic Test (LLNT) with Shear Wave Elastography

Group B (Control Group)

Description:

Thirty healthy control participants aged 25-40 years, free from symptoms of nerve irritation or compression, with normal neurological examination findings including normal reflexes, sensation, negative straight leg raising test, and normal motor strength. Participants will receive the same sciatic nerve tension tests in both sequences.

Treatment:

Diagnostic Test: Lower Limb Neurodynamic Test (LLNT) with Shear Wave Elastography