Scintigraphic Assessment of I- Transport in Metastatic Breast Cancer and Evaluation of I31I Ablative Therapy: (Part I) Radioiodide Imaging Study

Stanford University

Status: Completed

Conditions: Breast Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT00185809

BRSMTS0002

75632

NCT00185809

NIH

Details and patient eligibility

About

The purpose of this study is to examine breast cancers that express the protein (NIS) that may be found in malignant breast tissues and to evaluate proteins found in blood and their relationship to NIS, to test whether iodide can be concentrated by breast cells to possibly treat some breast cancers with radioactive iodine, and to calculate the amount of radioactive iodine entering breast cancer cells, how long your cancer retains the agent as well as how much is taken up by other organs, particularly the thyroid gland.

Full description

To demonstrate iodide uptake capacity of breast cancer metastases by imaging women with iodide radioisotope (123I) and calculating potential ablative dose of radioactive iodide (131I).

Enrollment: 25 estimated patients

Sex: Female

Ages: 18 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:- Only women diagnosed with breast cancer

• 18 years of age or older
• From whom informed consent can be obtained
• Patient is able to provide a fluid (e.g. cyst fluid)
• Patient with blood test that shows protein may allow iodide to accumulate in breast tissue
• Patient who's breast cancer cells accumulated I123 and held on to it for 24 hours Exclusion Criteria:- Males
• Children