Scintigraphic Comparison of Lung Deposition With Two Nebulizers During Invasive Mechanical Ventilation

Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Status: Terminated

Conditions: Post-operative Neurosurgery

Treatments: Other: Planar scintigraphy; Device: Vibrating-mesh nebulizer; Device: Jet Nebulizer; Drug: technetium-99m - Diethylenetriaminepentaacetic acid; Other: Preoperative spirometry

Study type: Interventional

Funder types: Other

Identifiers

NCT02450279

AeroVent-02

Details and patient eligibility

About

Many devices are available for nebulising drug solution during invasive mechanical ventilation. Vibrating-mesh nebulizers ensure the highest lung deposition output. A recent international survey on aerosol therapy during mechanical ventilation (Ehrmann et al. 2013) reported that jet nebulizers remained the mostly used.

The aim of this study is to compare lung deposition of a radiolabeled administered with both nebulizers during invasive mechanical ventilation by planar scintigraphy.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Invasive mechanical ventilation
• Healthy lungs

Exclusion criteria

• Discontinued procedure due to adverse events.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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20 participants in 2 patient groups

Nebulization with a vibrating-mesh nebulizer

Active Comparator group

Description:

Nebulization performed with a vibrating-mesh nebulizer

Treatment:

Other: Planar scintigraphy

Drug: technetium-99m - Diethylenetriaminepentaacetic acid

Other: Preoperative spirometry

Device: Vibrating-mesh nebulizer

Nebulization with a jet nebulizer

Active Comparator group

Description:

Nebulization performed with a jet nebulizer

Treatment:

Other: Planar scintigraphy

Drug: technetium-99m - Diethylenetriaminepentaacetic acid

Other: Preoperative spirometry

Device: Jet Nebulizer