Screening and Treatment of SAHS in Patients With Acute Ischemic Stroke

Peking University

Status: Unknown

Conditions: Ischemic Stroke; Sleep Apnea Syndrome

Treatments: Device: Bi level positive pressure ventilation; Device: bi-level positive airway pressure

Study type: Interventional

Funder types: Other

Identifiers

NCT02029183

2694-01

Details and patient eligibility

About

Ischemic stroke is a kind of common disease with great harm. In acute stage of stroke there is sharply increasing morbidity of sleep apnea hypopnea syndrome. Our suppose that treatment with noninvasive ventilation for patients with acute ischemic stroke should improve the functional prognosis（measuring with 90d modified Rankin score）.

Full description

In acute state of ischemic stroke，if patients with sleep apnea hypopnea syndrome may need additional respiratory management such bi-level positive airway pressure.We supposed the patients with stroke can take benefit of functional recovery form bi-level positive airway pressure. We choose the patients who suffered ischemic stroke in 48 hours ，then evaluate the respiratory status. Stroke patients who were diagnosed as sleep apnea hypopnea syndrome will accept additional treatment with bi-level positive airway pressure for 7 night（per night 6 hours）.Then the modified Rankin scale score and NIHSS will be recorded at 30 days and 90 days after stroke.

Enrollment: 120 estimated patients

Sex: All

Ages: 35 to 70 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ischeic stroke onset within 48 hours , NIHSS:4-15

Exclusion criteria

• mRs>2 before onset of enrollment severe hepatic renal insufficiency cancer in reached an advanced stage

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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120 participants in 1 patient group

bi-level positive airway pressure

Experimental group

Description:

bi-level positive airway pressure for 6 hour per night，total 7 days

Treatment:

Device: Bi level positive pressure ventilation

Device: bi-level positive airway pressure