Screening for Coronary Artery Disease USing Primary Evaluation With Coronary CTA in Aviation Medicine (SUSPECT)

UMC Utrecht

Status: Terminated

Conditions: Aviator's; Disease; Occupational Diseases; Coronary Artery Calcification; Coronary Artery Disease (CAD)

Treatments: Radiation: CT Angiography; Diagnostic Test: Exercise stress test

Study type: Interventional

Funder types: Other

Identifiers

NCT05508893

13-693/D

Details and patient eligibility

About

SUSPECT is a prospective, single-center, cohort study of 250 military aircrew at the Center for Man in Aviation, Royal Netherlands Air Force. All asymptomatic aircrew (≥40 years) are asked to undergo a coronary CT scan on a voluntary basis, following the exercise electrocardiograms performed at their routine aeromedical examination. Coronary Artery Calcium score (CACS) and CCTA findings are reported.

Enrollment: 250 patients

Sex: All

Ages: 40+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Military aircrew of the Royal Netherlands Air Force
• ≥ 40 years old
• Required to undergo cardiac screening (per military aviation regulations)

Exclusion criteria

• Typical angina

• Prior myocardial infarction

• Prior revascularization therapy (i.e. percutaneous coronary intervention (PCI) and/or coronary artery bypass grafting (CABG))

• Left ventricular ejection fraction <35%

• Does not comprehend study requirements, and/or is unwilling or unable to comply to study procedures

• CT-related contra-indications

  • Allergic to iodine contrast.
  • Renal insufficiency (GFR <60 ml/min/1.73m2, calculated with the Modification of Diet in Renal Disease (MDRD) calculator: http://nephron.org/mdrd_gfr_si.
  • Severe claustrophobia.
  • Uncontrolled irregular heart rhythm or tachycardia unresponsive to beta blockade
  • Pregnancy

Trial design

Primary purpose: Screening

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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250 participants in 2 patient groups

CT Angiography

Other group

Description:

Coronary CT Angiography will be performed on all individuals

Treatment:

Radiation: CT Angiography

Exercise stress test

Other group

Description:

An bicycle exercise stress test will be performed on all individuals

Treatment:

Diagnostic Test: Exercise stress test