Screening for Neurodevelopmental Disorders in Siblings of Children With Autism Diagnosed in Tertiary Centers (FRATSA)

University Hospital Center (CHU)

Status: Not yet enrolling

Conditions: Siblings; Autism Spectrum Disorder; Neurodevelopmental Disorders

Treatments: Diagnostic Test: Step 1 - Screening ; Step 2 - Clinical interview

Study type: Observational

Funder types: Other

Identifiers

NCT05512637

RECHMPL21_0358

Details and patient eligibility

About

In this study, a selective and multi-stages screening for neurodevelopmental disorders (NDD) in siblings of children with a confirmed ASD is done. The main aims are to estimate the prevalence of NDD among siblings and to evaluate the feasibility and acceptability of a standardized screening procedure.

Full description

Although NDD are frequent among siblings of children with ASD, their developmental screening is not yet sufficiently organized in routine practice. The needs and the characteristics of these siblings have yet to be better understood in order to define their developmental surveillance.

Enrollment: 384 estimated patients

Sex: All

Ages: 2 to 16 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Step 1: Brothers or sisters (including stepsisters and brothers); aged between 2 and 16 years; living in Occitanie; informed and express consent of parents ; affiliated to social security.
• Step 2: step 1 positive screening or parental concerns for child's development ; parental signed informed consent.

Exclusion criteria

• Parents (or child) refusal to participate; adopted brother or sister. Do not speak French

Trial design

384 participants in 1 patient group

neurodevelopmental disorders

Description:

Step 1 - Screening: the targeted sample is the siblings of the autistic children, these siblings being at risk of neurodevelopmental disorders. Step 2 - Clinical interview: All the children with a positive screening.

Treatment:

Diagnostic Test: Step 1 - Screening ; Step 2 - Clinical interview