Screening for Risk Factors of Prediabetes Among Adult Patients at Sohag University Hospital

Sohag University

Status: Enrolling

Conditions: PreDiabetes

Treatments: Diagnostic Test: urine analysis; Diagnostic Test: Alb/cr ratio; Diagnostic Test: fundus examination; Diagnostic Test: HbA1c; Diagnostic Test: ECG; Diagnostic Test: CBC; Diagnostic Test: lipid profile; Diagnostic Test: CRP; Diagnostic Test: serum creatinine .

Study type: Observational

Funder types: Other

Identifiers

NCT05864183

Soh-Med-23-04-20MS

Details and patient eligibility

About

• Prediabetes is an intermediate state of hyperglycemia with glycemic parameters above normal but below the diabetes threshold..
• during the average 3 years of follow-up Prediabetes is diagnosed based on laboratory tests: fasting plasma glucose level (100-125 mg/dl) ;HbA1c, (5.7-6.4%) or plasma glucose level after an oral glucose tolerance test ( 140-199 mg/dl).
• Reports estimate that more than 470 million people will have prediabetes by 2030.
• According to an expert panel of the American Diabetes Association, up to 70% of individuals with prediabetes will eventually develop diabetes.
• Observational evidence suggests as association between prediabetes and complications of diabetes such early nephropathy(10%) , small fiber neuropathy(18-25 %), early retinopathy (8-12%) and risk of macrovascular disease (52%) .
• Screening for prediabetes is designed to save lives or enhance an individual's quality of life by early detection so that screening will minimize the risk of developing diabetes or its complications .

Full description

• In this case control study we aim to screen for risk factors of prediabetes among adult patients to minimize the risk of developing diabetes or its complications .
• Prediabetes screening is also required to minimize medical costs such as hospitalization, outpatient care, surgery, medications, and laboratory test costs .
• Several studies had shown efficacy of lifestyle interventions in diabetes prevention by targeting obesity with increase in physical activity and dietary changes with a relative risk reduction of 40%-70% in adults with prediabetes ,also there is increasing evidence to prove the efficacy of pharmacotherapy in prevention of diabetes in adults with prediabetes

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adult patient above 18 years old .

Exclusion criteria

• all patients known to be diabetics .
• pregnancy .
• chronic depleting diseases,
• Those who were taking drugs known to influence blood glucose levels e.g. metformin, thiazolidinedione and steroids.

Trial design

200 participants in 2 patient groups

case group

Description:

prediabetic

Treatment:

Diagnostic Test: urine analysis

Diagnostic Test: fundus examination

Diagnostic Test: CBC

Diagnostic Test: lipid profile

Diagnostic Test: CRP

Diagnostic Test: serum creatinine .

Diagnostic Test: Alb/cr ratio

Diagnostic Test: HbA1c

Diagnostic Test: ECG

control group

Description:

non prediabetic

Treatment:

Diagnostic Test: urine analysis

Diagnostic Test: fundus examination

Diagnostic Test: CBC

Diagnostic Test: lipid profile

Diagnostic Test: CRP

Diagnostic Test: serum creatinine .

Diagnostic Test: Alb/cr ratio

Diagnostic Test: HbA1c

Diagnostic Test: ECG