Screening for Uterine Cavity Abnormalities in Women Scheduled for IVF

Assiut University

Status: Completed

Conditions: Infertility

Treatments: Device: Office hysteroscopy; Radiation: three dimensional ultrasound

Study type: Interventional

Funder types: Other

Identifiers

NCT02598921

IVF

Details and patient eligibility

About

Evaluation of the endometrial cavity is an important step in the infertility work-up, particularly if assisted reproductive therapy is planned. The aim is to identify possible endometrial abnormalities that may impair implantation.Undiagnosed endometrial abnormalities are present in 11 to 45% of women scheduled for in vitro fertilization (IVF).Traditionally, two dimensional transvaginal ultrasound (2D TVUS) and hysterosalpingography (HSG) are the basic methods for assessment of the endometrial cavity. However, these imaging modalities have shown high false negative rates among infertile women, a finding that could confine their rule to initial screening rather than definite diagnosis.

Office hysteroscopy (OH) is the gold standard for evaluation of the endometrial cavity. Although the endoscopic approach has been proven to increase pregnancy rate in women who experienced prior implantation failure, evidence on treatment of unsuspected hysteroscopically-diagnosed endometrial lesions, to improve IVF outcome, is still lacking. Nevertheless,clinicians tend to use OH routinely prior to IVF because the psychological and financial burden that infertile couples may experience as a consequence of failed IVF cycle is unjustifiable.Yet, costs and invasiveness of OH counteract its global implementation to all women prior to IVF.

Enrollment: 120 patients

Sex: Female

Ages: 20 to 40 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• History of primary infertility
• Normal uterine cavity on HSG
• Women were selected for IVF therapy.

Exclusion criteria

• Women with known diagnosis of uterine abnormality by office hysteroscopy

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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120 participants in 2 patient groups

Three dimensional ultrasound

Other group

Description:

Three dimensional ultrasound evaluated the uterine cavity for cavitary lesions

Treatment:

Radiation: three dimensional ultrasound

Office hysteroscopy

Other group

Description:

Office hystrescopy evaluated the uterine cavity for cavitary lesions

Treatment:

Device: Office hysteroscopy