Screening in Oculopharyngeal Muscular Dystrophy

University of Florida

Status: Completed

Conditions: Oculopharyngeal Muscular Dystrophy

Treatments: Procedure: Videofluoroscopic swallowing study; Other: Eating Assessment Tool-10; Other: Functional Oral Intake Scale

Study type: Observational

Funder types: Other

Identifiers

NCT02877784

IRB201601374

Details and patient eligibility

About

Oculopharyngeal muscular dystrophy (OPMD) is a rare myopathic disease that results in progressive degeneration of the oral and pharyngeal muscular, resulting in severe dysphagia and dysarthria. OPMD is considered a rare disease; therefore, limited research is available on the natural progression of the disease or the utility of biomarkers to identify swallowing impairment. The aim of this study is:

1. To identify accurate, reliable and non-invasive clinical markers of swallowing impairment
2. To determine the discriminate ability of these markers to identify impairments in swallow safety and swallowing efficiency.

Full description

Participants will be recruited from the Neurology clinic at the University of Florida. The single evaluation will occur in the PIs research laboratory at the University of Florida, Gainesville, Florida.

Enrollment: 8 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• diagnosis of oculopharyngeal muscular dystrophy
• no allergies to barium or capsaicin,
• no tracheotomy or mechanical ventilation
• no significant concurrent respiratory disease (e.g., COPD).

Exclusion criteria

• Pregnant Women

Trial design

8 participants in 1 patient group

Screening

Description:

Participants enrolled will undergo testing of the swallowing mechanism

Treatment:

Other: Eating Assessment Tool-10

Other: Functional Oral Intake Scale

Procedure: Videofluoroscopic swallowing study