Screening of Healthy Adults for Genetic Variations That Control Fatty Acid Processing

Wake Forest University (WFU)

Status: Completed

Conditions: Healthy

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT01516125

P50AT002782 (U.S. NIH Grant/Contract)

IRB00016822

Details and patient eligibility

About

The purpose of this research study is to screen healthy African American and Caucasian persons for specific differences in genes that control how fats are processed in the body.

Full description

Healthy African American and Caucasian persons will be screened for specific differences in genes that control how fats are processed in the body. Persons with the needed genotypes will be added to a database of healthy persons who may be asked to join a larger study comparing differences in diet on lipid metabolism and inflammatory biomarkers as well as future studies. A key hypothesis for the larger study is that variations in genes involved in lipid metabolism play a role in determining levels of long chain polyunsaturated fatty acids (LC-PUFAs).

Enrollment: 458 patients

Sex: All

Ages: 21 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Be Caucasian or African American between 21-65 years of age
• Be healthy and free of any major illness
• Be a nonsmoker
• Have an intact gallbladder
• Have TG < 150 and blood pressure less than 130/90
• Must be willing to be re-contacted for future studies

Exclusion criteria

• Not have: myocardial infarction, vascular surgery or stroke within the past year
• Not be taking niacin, more than 100 mg aspirin/day or montelukast allergy medications
• BMI equal to or greater than 30 or less than 19
• Fasting glucose greater than 125 mg/dl
• Pregnancy

Trial design

458 participants in 1 patient group

Screening only - no intervention