Screening of Hereditary Upper Gastrointestinal Cancer in China

Peking University

Status: Unknown

Conditions: Improve the Screening Criteria of Chinese Hereditary Upper Gastrointestinal Tumors

Treatments: Diagnostic Test: Gene detection

Study type: Observational

Funder types: Other

Identifiers

NCT03130621

CGOG1012

Details and patient eligibility

About

Through exploring the specific genetic mutations in the upper gastrointestinal tract tumors with a family history and specific clinical pathological types，we establish a complete family and follow-up system，in order to improve the screening criteria of Chinese hereditary upper gastrointestinal tumors and carry on primary prevention of disease.

Enrollment: 500 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

Patients with gastric cancer, esophageal adenocarcinoma, or duodenal adenocarcinoma meet one of the following criteria:

1. age≤30;
2. age≤35，gastric cancer with special pathological types;
3. age≤50，≥one first-degree relative of a malignant tumor;
4. ≥ two first-degree／second-degree relatives of a malignant tumor，and ≥one first-degree relative;
5. have ≥two types of malignancies，and age ≤50 at the first time of diagnosis;
6. MSI or dMMR of tissue specimen;

Patients with esophageal squamous cell carcinomas meet one of the following criteria:

1. ≥ two first-degree／second-degree relatives of a malignant tumor，and ≥one first-degree relative;
2. have ≥two types of malignancies，and age ≤50 at the first time of diagnosis;
3. MSI or dMMR of tissue specimen;

Exclusion criteria

• Patients do not meet one of the inclusion criteria;

Trial design

500 participants in 2 patient groups

Adenocarcinoma of upper digestive tract

Description:

Early-onset carcinomas ; Family History of Malignancy; Special pathological type; MSI or dMMR; Multiple primary malignant tumors;

Treatment:

Diagnostic Test: Gene detection

Esophageal squamous cell carcinoma

Description:

Family History of Malignancy; Multiple primary malignant tumors; MSI or dMMR;

Treatment:

Diagnostic Test: Gene detection