Screening of Malignant Hyperthermia Susceptible Individuals

Peking University

Status: Enrolling

Conditions: Malignant Hyperthermia

Study type: Observational

Funder types: Other

Identifiers

NCT05402839

MR-11-22-002000

Details and patient eligibility

About

This study intends to target patients who underwent surgery under general anesthesia during the study period and developed malignant hyperthermia during or after surgery. Therefore, the total sample size was estimated to be about 50 people based on the past incidence of this rare disease. Every year, about 20 patients and their families who developed malignant hyperthermia during or after surgery will participate in this nationwide study (estimated by the current incidence of malignant hyperthermia), and about 1-5 patients will be admitted to Peking University Third Hospital participate in this research. Relevant specimens were collected from malignant hyperthermia (MH) patients and their family members for genetic analysis to determine the mutation of MH-related pathogenic gene loci.

Enrollment: 50 estimated patients

Sex: All

Ages: Under 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients undergoing surgery under general anesthesia during the study period developed malignant hyperthermia during or after surgery.

Exclusion criteria

• Malignant hyperthermia was ruled out by later treatment and diagnosis;
• The patient or family member refuses to be recruited.