Screening of Niemann-Pick Disease, Type C in a Psychiatric Population (NPCPsy)
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Details and patient eligibility
About
Niemann-Pick disease, Type C is a rare genetic disorder characterized by a failing in intracellular cholesterol transport, inducing an accumulation of sphingolipids in the brain.
Neurological signs are at the forefront of the disease. There are also psychiatric signs of psychotic kind among 28 to 45 % of patients according to studies, and a thirty cases were published. These signs can be concomitant with neurological signs or precede them.
Is is likely that psychotic disorders are the first signs of a Niemann-Pick disease not yet non encore diagnosed for some patients. Yet, no prevalence study for this disease in a psychiatric population of patients currently exists. In response to this problem this study proposes to search patients whose disease could be of organic origin or patients whose disease is suspected, based on clinical data. The diagnosis will be confirmed certified with a genetic and/or biochemical test.
Full description
The aim of this study is to search among a population psychotic adult patients, the ones that present a Type C Niemann-Pick disease in order to to estimate the prevalence.
Enrollment
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Volunteers
Inclusion criteria
- Hallucinations visual
- Confusion
- Catatonia
- Significant fluctuation of symptoms
- Unusual or paradoxical reaction to the treatment
- Progressive cognitive deterioration
Exclusion criteria
- Patients under 18 years
- Patients unable to give their free consent and without a legal representative
- Breastfeeding or pregnant women
Trial design
22 participants in 1 patient group
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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