Screening of Specific Genes for Pigmented Villous Nodular Synovitis

Peking University

Status: Completed

Conditions: Pigmented Villonodular Synovitis

Treatments: Procedure: Arthroscopic synovectomy

Study type: Observational

Funder types: Other

Identifiers

NCT04955535

M201947901

Details and patient eligibility

About

This study retrospectively analyzed the history of present illness of PVNS patients in our hospital. The enrolled patients were followed up by telephone to follow up their postoperative recovery and living conditions. Take the patient's pathological specimens for immunohistochemical testing, evaluate the relationship between the expression of different molecular targets, clinical manifestations and patient prognosis, and explore new molecular targets related to disease diagnosis and treatment.

Full description

This study retrospectively analyzed the symptoms, time of onset, injury history, laboratory examinations, imaging examinations, and intraoperative conditions of PVNS patients in our hospital. The enrolled patients were followed up by telephone to follow up their postoperative recovery and living conditions (VAS score, SF-36 score). Take the patient's pathological specimens for immunohistochemical testing, evaluate the relationship between the expression of different molecular targets, clinical manifestations and patient prognosis, and explore new molecular targets related to disease diagnosis and treatment.

Enrollment: 60 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Clinical diagnosis of pigmented villonodular synovitis.
2. Clinical diagnosis of giant cell tumor of tendon sheath

Exclusion criteria

1. No surgical treatment.
2. There were no pathological specimens during the operation.
3. The age of the patient is less than 18 years old or more than 60 years old.
4. The operation record shows nodular type.