Search Allelic Imbalance of Expression of BRCA Genes in Hereditary Risk of Breast and/or Ovarian Cancer (EXSAL)

Centre Francois Baclesse

Status and phase

Completed

Phase 2

Conditions

Hereditary Breast and Ovarian Cancer Syndrome

Treatments

Genetic: blood collection

Study type

Interventional

Funder types

Other

Identifiers

NCT01333748

EXSAL

2009-A00833-54 (Registry Identifier)

Details and patient eligibility

About

The purpose of this study is to determine proportion of patients presented a search allelic imbalance of expression of genes BRCA 1 and 2 in population with hereditary breast and/or ovarian cancer risk and negative for deletion mutation BRCA 1 and 2 genes

Enrollment

530 estimated patients

Sex

Female

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

For patients

Women with breast cancer and / or ovarian cancer meet criteria suggestive of a hereditary predisposition
Deleterious mutation of BRCA1 and BRCA2 sought and not highlighted
Age ≥ 18 years
Agreeing to participate in the study (a collection of signed informed consent)

For control population

Women with no history of breast and / or ovarian cancer and no family history of breast and / or ovarian cancer among family members on the 1st and 2nd degree before age 50 for breast cancer and before 60 years for ovarian cancer
Agreeing to participate in the study (a collection of signed informed consent)

Exclusion criteria

For patients:

Patients with a known deleterious mutation in BRCA1 and BRCA2
Patients do not meet criteria suggestive of a hereditary predisposition
Persons deprived of liberty or under guardianship (including guardianship)

For control population:

Males
Personal or family history of breast and / or ovarian cancer (breast or ovarian cancer in their family experienced 1st and 2nd degree before age 50 for breast cancer before age 60 for cancer ovarian)
Persons deprived of liberty or under guardianship (including guardianship)