Seattle Cardiorenal Remote Ischemic Preconditioning Trial (SCRIPT)
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Details and patient eligibility
About
Remote Ischemic Preconditioning (RIPC) is a treatment that may be associated with improved outcomes after cardiac surgery. It can be elicited noninvasively by using a tourniquet to elicit transient ischemia over a lower extremity. It is thought to promote anti-inflammatory and cell survival pathways, and thus protect remote organs against future ischemic injury. We hypothesize that compared to sham treatment, RIPC will be associated with decreased post-operative acute kidney, myocardial, and lung injury.
Full description
In children undergoing cardiac surgery and cardiopulmonary bypass (CPB), our primary aims are to determine whether RPC is associated with: 1) decreased AKI and 2) decreased acute myocardial injury. Secondary aims include investigating the effects of RPC on post-procedure: 1)acute lung injury and 2) morbidity/mortality.
Enrollment
Sex
Ages
Volunteers
Inclusion criteria
Age birth to 18 years Cardiac surgery with planned cardiopulmonary bypass
Exclusion criteria
Any contraindication to compression of lower extremity/extremities Body weight <2 kg Active infection going into surgery On renal replacement therapy (RRT) or mechanical circulatory support going into surgery On inotropic support going into surgery
Trial design
Primary purpose
Allocation
Interventional model
Masking
90 participants in 2 patient groups
Trial contacts and locations
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Data sourced from clinicaltrials.gov
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