Sebum Collection and Skin Barrier Function Analysis

University of California (UC) Davis

Status: Completed

Conditions: Atopic Dermatitis; Aging; Acne; Smoking

Treatments: Other: Skin Surface Lipid Collection and Skin Barrier Function

Study type: Observational

Funder types: Other

Identifiers

NCT03112876

605131

Details and patient eligibility

About

The goal is this study is to evaluate how the skin surface lipid composition is correlated with overall sebum production, barrier function, and inflammatory disease status. We hypothesize that there will be differences in the skin surface composition among subjects of various groups:

1. Young vs older healthy population
2. Atopic dermatitis vs Acne vs Healthy controls
3. Active smokers vs non-smoker controls

Full description

This study will be conducted through the use of painless tapes to collect lipid. These will be applied to the skin and removed. Secondly, the barrier function will be evaluated through the use of non-invasive painless devices that measure sebum, skin water loss, and skin hydration.

Enrollment: 41 patients

Sex: All

Ages: 12+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Subjects that are 12 years of age or older

Exclusion criteria

• None

Trial design

41 participants in 5 patient groups

Young Age - Healthy

Description:

These subjects are between the age of 12 and 35 years. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.

Treatment:

Other: Skin Surface Lipid Collection and Skin Barrier Function

Old Age -Healthy

Description:

These subjects are 55 years of age and older. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.

Treatment:

Other: Skin Surface Lipid Collection and Skin Barrier Function

Active Smoker

Description:

These subjects are active smokers who smoke often. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.

Treatment:

Other: Skin Surface Lipid Collection and Skin Barrier Function

Dermatological skin condition: Acne vulgaris

Description:

These subjects have acne vulgaris. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.

Treatment:

Other: Skin Surface Lipid Collection and Skin Barrier Function

Dermatological skin condition: Atopic dermatitis

Description:

These subjects have atopic dermatitis. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.

Treatment:

Other: Skin Surface Lipid Collection and Skin Barrier Function