Second Bowel Preparation for Colonoscopy Failure

Asan Medical Center

Status and phase: Terminated; Phase 4

Conditions: Colonoscopy Failure; Poor Bowel Preparation

Treatments: Drug: polyethylene glycol; Drug: polyethylene glycol, Bisacodyl

Study type: Interventional

Funder types: Other

Identifiers

NCT01510977

2009-0733

Details and patient eligibility

About

Colonoscopy is a basic but important tool to diagnose and treat lesions of the colon. Proper colon cleansing is essential for colonoscopy to be performed with a good quality. Inadequate bowel preparation leads to longer colonoscopic insertion time and patient discomfort, as well as inadequate diagnostic yield of colonic lesions. Frequency of colonoscopy failure due to bad bowel preparation is reported to be 0.3% to 6.5 percent, and the rate increases with liver cirrhosis, constipation, dementia, stroke, or administration of tricyclic antidepressants. In case of colonoscopy failure due to bad bowel preparation, the second colonoscopy can be performed with either adding a colon cleansing solution immediately, or it can be performed after a few days with colon cleansing agent together with prokinetics. These different kinds of bowel preparations after first colonoscopy failure have not been compared.

Enrollment: 150 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• First colonoscopy failure due to inadequate bowel preparation

Exclusion criteria

• younger than 18 years old
• presence of inflammatory bowel disease
• pregnant
• lactating
• refusal

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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150 participants in 2 patient groups

PEG

Active Comparator group

Description:

2L of polyethylene glycol addition immediately after first colonoscopy failure

Treatment:

Drug: polyethylene glycol

PEG + bisacodyl

Experimental group

Description:

One week after initial colonoscopy failure, conventional amount (5L) of polyethylene glycol together with bisacodyl administration

Treatment:

Drug: polyethylene glycol, Bisacodyl